About pilocarpine hcl overview how to use side effects precautions storage drug interactions overdose more this medication is used to treat symptoms of dry mouth due to a certain immune disease sjogrens syndrome or from saliva gland damage due to radiation treatments of the headneck for cancer. Pilocarpine hydrochloride has been used to stimulate salivary secretions in mice. Salagen pilocarpine hydrochloride dose, indications. Each ml of pilocarpine hydrochloride ophthalmic solution contains. Pilocarpine is a choline ester miotic and a positively charged quaternary ammonium compound. Pilocarpine hydrochloride is a hygroscopic, odorless, bitter tasting white crystal or powder which is soluble in water and alcohol and virtually insoluble in most nonpolar solvents. Packaging 5, 10, 50 g in poly bottle biochemphysiol actions pilocarpine is alkaloid isolated from the shrub pilocarpus species.
Salagen pilocarpine hydrochloride tablet, film coated. It may also help with chewing, tasting, and swallowing. Pilocarpine hydrochloride information, side effects, warnings. Pilocarpine oral tablet 5mg drug medication dosage information. Pilocarpine is used to treat dry mouth caused by sjogrens syndrome, or. Learn about the reported side effects, related class drugs, and how these medications will affect your daily lifestyle. Safety data sheet northwest missouri state university. When pilocarpine is used to treat dry mouth in people who have sjogrens syndrome, it is usually taken four times a day. Pilocarpine hydrochloride dosage and administration administration oral administration. Pilocarpine side effects, dosage, interactions drugs. Nov 09, 2018 pilocarpine affects the nervous system and increases saliva secretion in the mouth.
Pilocarpine hydrochloride monograph for professionals. Safety data sheet according to federal register vol. Certificate of analysis coa product information sheet pdf. The following table lists the ndcs and labelers of pilocarpine hydrochloride.
Disclaimer the sds samples above are collected from the internet by chemblink and displayed here for the tutorial purpose only. Pilocarpine eye drops fda prescribing information, side. Nov 30, 2017 systemic exposure to pilocarpine was evaluated in 14 healthy subjects administered 2 drops of pilocarpine hydrochloride ophthalmic solution 4% to both eyes four times daily for eight days. Pilocarpine, in appropriate dosage, can increase secretion by the exocrine glands. Choose how to save on pilocarpine hcl in redmond, wa 98052 home delivery how it works fast. Pilocarpine tablets are used to treat dryness of the mouth and throat caused by a decrease in the amount of saliva that may occur after radiation treatment for cancer of the head and neck or in patients with sjogrens syndrome. Pilocarpine ophthalmic side effects, dosage, interactions. The sweat, salivary, lacrimal, gastric, pancreatic, and intestinal glands and the mucous cells of the respiratory tract may be stimulated. Pilocarpine and its degradation products are excreted in the urine. Lgm pharma offers this active ingredient but not the finished dosage forms. Section 1 chemical product and company identification. It has also been used to induce status epilepticusse in rat. Identification of the substancemixture and of the company undertaking. Buy pilocarpine hcl generic isopto carpine, pilocar.
Inquire about dmf, cgmp, price, availability, samples, sourcing, purity and more. Jan 01, 2017 pilocarpine tablets are used to treat dryness of the mouth and throat caused by a decrease in the amount of saliva that may occur after radiation treatment for cancer of the head and neck or in patients with sjogrens syndrome. Pilocarpine works by causing the pupil of the eye to shrink and decreasing the amount of fluid within the eye. Management of chronic simple glaucoma, chronic and acute angleclosure glaucoma available dosage from the hospital. Eight samples of pilocarpine hydrochloride had tablets that exceeded the usp upper limit for strength.
Salagen tablets contain pilocarpine hydrochloride, a cholinergic agonist for oral use. Chemical product and company identification product name. This medicine may help you speak without having to sip liquids. Systemic exposure to pilocarpine was evaluated in 14 healthy subjects administered 2 drops of isopto carpine pilocarpine hydrochloride ophthalmic solution 4% to both. Pilocarpine hcl is a nonselective muscarinic acetylcholine receptor agonist. Isopto carpine pilocarpine hydrochloride ophthalmic solution is a cholinergic agonist prepared as a sterile topical ophthalmic solution.
It works by stimulating certain nerves to increase the amount of saliva you produce, making it easier and more comfortable to speak and swallow. Pilocarpine ophthalmic drops, solution 1pct drug medication dosage information. Pilocarpine hydrochloride ophthalmic solution 1%, 2%, and 4% has been used as a miotic for the clinical therapy of primary openangle. Pilocarpine may stimulate the mucous cells of the respiratory tract and increase bronchial smooth muscle tone and airway resistance. Pilocarpine hydrochloride tablets contain pilocarpine hydrochloride, a cholinergic agonist for oral use. Pilocarpine hydrochloride ophthalmic solution is a muscarinic cholinergic agonist indicated for the reduction of elevated intraocular pressure iop in patients with openangle glaucoma or ocular hypertension the management of acute angleclosure glaucoma the prevention of postoperative elevated iop associated with laser surgery the induction of miosis. Nov 09, 2018 pilocarpine reduces the amount of fluid in the eye, which decreases pressure inside the eye. Pilocarpine ophthalmic for the eyes is used to treat glaucoma or.
We will continue to use fair share allocation of otc product to combat shortages and strive to get orders out in a timely manner. Pilocarpine hydrochloride information, side effects. Although pilocarpine salts in ophthalmic solution decompose into isopilocarpine. The active ingredient is represented by the chemical structure. Take this medication by mouth with or without food, usually 34 times daily, or as directed by your doctor to reduce your risk of side effects, your doctor may direct. Pilocarpine hydrochloride 54717 451538902 cymit quimica s. However, due to its side effects it is no longer typically used in the long term management. May cause eye, skin, or respiratory system irritation.
Dec 08, 2016 isopto carpine pilocarpine hydrochloride ophthalmic solution 1%, 2% and 4%. As eye drops it is used to manage angle closure glaucoma until surgery can be performed, ocular hypertension, primary open angle glaucoma, and to bring about constriction of the pupil following its dilation. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Pilocarpine is a medication used to reduce pressure inside the eye and treat dry mouth. When pilocarpine is used to treat dry mouth caused by radiotherapy in people who have head and neck cancer, it is usually taken three times a day. In a multipledose pharmacokinetic study in male volunteers following 2 days of 5 or 10 mg of oral pilocarpine hydrochloride tablets given at 8 a.
Pilocarpine hydrochloride ophthalmic solution is a cholinergic agonist prepared as a sterile topical ophthalmic solution. Pilocarpine affects the nervous system and increases saliva secretion in the mouth. Pilocarpine toxicity and the treatment of xerostomia article pdf available in journal of emergency medicine 264. Pilopine hs pilocarpine hydrochloride ophthalmic gel 4%. Buy pilocarpine hcl generic isopto carpine, pilocar, salagen. Pilocarpine hydrochloride can be used in the medical management of glaucoma, especially openangle glaucoma, in those cases in which the intraocular pressure can be controlled adequately by the topical administration of pilocarpine. Following oral administration of pilocarpine the elimination halflife ranges from 0. Stability of pilocarpine hydrochloride and pilocarpine. Pilocarpine is a natural alkaloid extracted from plants of the genus pilocarpus with cholinergic agonist activity. Pilocarpine ophthalmic drops, solution 1pct drug medication. Pilocarpine hydrochloride pilocarpini hydrochloridum contd.
Important update all sales after march 2, 2020 are final and nonreturnable for covid19 related items. Pilocarpine hydrochloride northwest missouri state. One reagent lane fair lawn, nj 07410 for information in north america, call. A comparison of c max values on days 5 and 8 indicated that pilocarpine concentrations in plasma reached steadystate following topical administration of. How to use pilocarpine hcl drops to apply eye drops, wash your hands first. Pilocarpine belongs to a class of drugs known as cholinergic agonists. Colorless, translucent crystals or white crystalline powder function. As a cholinergic parasympathomimetic agent, pilocarpine predominantly binds to muscarinic receptors, thereby inducing exocrine gland secretion and stimulating smooth muscle in the bronchi, urinary tract, biliary tract, and intestinal tract. Salivary gland scintigraphy was positive for damage to glands. Synonyms pilocarpine hcl unii 0ww6d218xj cas number 54717 weight average. Pilocarpine is used to treat dry mouth caused by sjogrens syndrome, or by radiation to treat head and neck cancer. Material may be irritating to the mucous membranes and upper respiratory tract. Safety data sheet memorial university of newfoundland.
The amount of isopilocarpine found ranged from 1 to 6. Some combination preparations of pilocarpine contain sodium bisulfite and should be used with caution in patients with a known sulfite hypersensitivity, especially in patients with a history of asthma. Pdf pilocarpine toxicity and the treatment of xerostomia. Concentration pilocarpine hydrochloride 54717 2002125 614017001 sheets you need to deploy.
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