This msds has been prepared according to the hazard criteria of the controlled products regulations cpr and the msds contains all of the information required by the cpr. Estrogens suppress a behavioral phenotype in zebrafish mutants of. Ticlopidine is a first generation thienopyridine adpp2y12 receptor inhibitor that exhibits antithrombotic and cardioprotective activities. Ticlopidine hydrochloride safety data sheet section 2.
The objective of the current study was to develop a simple, precise and accurate spectrophometric assay method and validated for determination of ticlopidine hydrochloride in solid pharmaceutical dosage forms. View and buy high purity ticlopidine hydrochloride from tocris bioscience. Ticlopidine hydrochloride analytical standard, for drug analysis. Ticlopidine binds to the p2y12 receptor, preventing changes in the glycoprotein iibiiia conformation and suppressing fibrinogenplatelet binding. Some people may have such side effects as diarrhea, skin rash, stomach or intestinal discomfort. Aspirinpotentiates the effect of ticlopidine on platelets concurrent usenotrecommended. Material safety data sheet of ticlopidine hydrochloride.
Section 5 fire fighting measures general information. Ticlopidine hydrochloride 53885351 cayman chemical. Precautionary statements p264 wash contaminated skin thoroughly after handling. As in any fire, wear a selfcontained breathing apparatus in pressuredemand, mshaniosh approved or equivalent, and full protective. Rubidium acetylene carbides burns with slightly warm hydrochloric acid. Ticlid ticlopidine hydrochloride is a platelet aggregation inhibitor used to prevent blood clots after a recent heart attack or stroke, and in people with certain disorders of the heart or blood vessels. Page 7 of 9 msds dimethylformamide behaviorcentral nervous system convulsions, muscle weakness and oth er symptoms similar to that of acute ingestion, respiration dyspnea.
Sigmaaldrich offers a number of ticlopidine hydrochloride products. Keep ticlid ticlopidine hcl out of reach of children. Keep in a tightly closed container, stored in a cooled, dry, ventilated area. It can cause gastrointestinal tract irritation with heartburn, abdominal pain, nausea, vomiting or diarrhea. Ticlopidine hydrochloride is an adenosine diphosphate adp receptor inhibitor against platelet aggregation with ic50 of 2.
Ticlopidine hydrochloride is metabo lized extensively by the liver, no intact ticlopidine hydrochloride is detected in the urine. Valve protection caps must remain in place unless container is secured with valve outlet piped to use point. Ticlopidine c14h14clns cid 5472 structure, chemical names, physical and. First aid measures description of first aid measures. Material safety data sheet tizanidine hcl sc200148 hazard alert code key. Product name ticlopidine hydrochloride sigmaaldrich. Ticlid ticlopidine hcl should be used only as directed by your doctor. Safety data sheet product name lidocaine hydrochloride. Hold eyelids apart and flush eyes with plenty of water for at. Material safety data sheet hydrochloric acid section 1 chemical product and company identification msds name. India veritas house, 70 mint road, fort, mumbai 400 001. In patients receiving an intracoronary stent, following successful stent implantation, ticlopidine therapy may be continued for up to 30 days.
Extreme high moderate low section 1 chemical product and company identification product name tizanidine hcl statement of hazardous nature considered a hazardous substance according to osha 29 cfr 1910. However, the results of one study atlast trial suggest that the frequency of stent thrombosis and other adverse ischemic events remains low even when ticlopidine is discontinued after 2 weeks of therapy. Clonidine hydrochloride safety data sheet supersedes revision. Pdf a novel inhibitor of plasminogen activator inhibitor1 provides. Unme tabolized ticlopidine hydrochloride is a minor component in plasma after a single dose, but at steady state, ticlopidine hydrochloride is the major component. Ticlopidine hydrochloride supplier cas 53885351 tocris. Federal occupational safety and health administration standard 29 cfr 1910. S45 in case of accident or if you feel unwell seek medical advice immediately show the label. State equivalent standards, and canadian workplace hazardous materials identification system standards cpr 4. Cimetidinepmetabolism of ticlopidine and may qthe risk of toxicity. Sds of ticlopidine hydrochloride, safety data sheets, cas. The students ttest, welchs ttest and the paired ttest were used.
Safety data sheet tris hydrochloride precautionary. No test data on mobility of the components available. Ticlopidine hydrochloride monograph for professionals. Lidocaine hydrochloride and epinephrine injection 1. A pvalue of hydrochloride n 31 or ticlopidine hydrochloride n 43. S26 in case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Sarpogrelate hydrochloride may therefore maintain the cbf at a lower mbp than ticlopidine hydrochloride, even though the mbp reduction is about the same or greater.
Uranium phosphide reacts with hydrochloric acid to release spontaneously flammable phosphines. Search results for ticlopidine hydrochloride at sigmaaldrich. As with most organic solids, fire is possible at elevated temperatures or. Ticlopidine is a thienopyridine which, when metabolized by the body, irreversibly blocks the p2y12 component of the adp receptor on the surface of. The first generic ticlopidine hydrochloride was fda approved in 1999. Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humans. P270 do not eat, drink or smoke when using this product. Identification of the substancemixture and of the companyundertaking. Material safety data sheet of ticlopidine hydrochloride contains identification of substance and details of the supplier of the safety data sheet. Ticlopidine inhibits liver cyp2c19 and cyp2b6 and thus can affect blood levels of medications metabolized by these systems.
Pdf inhibition of plasminogen activator inhibitor pai1 is useful to treat several. Safety data sheet according to federal register vol. Chemical product and company identification manufacturer name and. Ticlopidine trade name ticlid is an antiplatelet drug in the thienopyridine family which is an. Hydrochloric acid, 37% ww safety data sheet according to federal register vol. Hydrochloric acid, 10% vv safety data sheet according to federal register vol. Side effects of ticlid ticlopidine hcl, warnings, uses. Download product insert pdfdownload safety data sheet sds pdf. Lithium silicide in contact with hydrogen chloride becomes incandescent. Hold eyelids apart and flush eyes with plenty of water for at least 15 minutes. Ticlopidine hydrochloride hazard statements h302 harmful if swallowed. If any of these problems are persistent, or if you are concerned.
However, we make no warranty of merchantability or any other warranty, express or implied, with. Identification of the substancemixture and of the companyundertaking 1. Ticlopidinepmetabolism and the risk of toxicity of theophylline. Safety data sheet according to 29cfr19101200 and ghs rev. Material safety data sheet msds hexane section 1 product and company identification product product name. The mbp range associated with preservation of cbf depends on a balance between the contractility of resistant cerebral arteries and. Doxorubicin hydrochloride solution for injection 2 mgml.
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